Intelligence
- book
- patent
- 3d models
- foldable guitar
- research
Honors
Bolin discovers
Patents
During her volunteer at senior homes performing music for seniors, Bolin met a senior friend, Mary, who was always there listening to her music and broke into tears every time listening to Beethoven. Talking to her and knowing that she had trouble sleeping every night due to always congested sinuses, Bolin felt the urgency of the existence of a breathing assist mouthpiece device to help the many of the seniors who have breathing problems while sleeping. With a few other friends, Bolin designed a mouthpiece device to help people with congested sinuses to breathe freely through mouth. Producing one for Mary to try it on and based on the feedback, Bolin is currently designing an improvement that includes an auto-adjustment feature that automatically adjusts the opening angle and force based on heartsbeat & oxygen level in blood, a feedback app that receives data from the mouthpiece to monitor the sleeping quality of the user and the effectiveness of the mouthpiece, and a transition of the upper and lower archwire into hollow tubes with micro-pores that is able to effuse moisturizer and medicine that is able to cure the congested sinuses.Bolin also designed a personal protective device with adjustable angle during Covid-19 pandemic.
Published Books and Research Paper
Research
Intern at Professor Zi Chen’s Lab at Brigham and Women’s Hospital (Feb. 2023-Present) Developed multi-layer, self-oscillating bionic vocal folds that can successfully produce both vocal register and falsetto register by manipulating the size and property of different layers of the vocal folds; conducted preliminary proof of concept for an intragastric capsule battling diabetes using Arduino; Designed a no-perforation magnetic staple coated with biocompatible adhesives to accomplish gastrointestinal anastomosis that reduces anastomosis leakage; designed and tested soft robots moving with high-voltage power supply.
Click on the picture to see a video of how does the bluetooth controls the balloon.
Exploring the Interactions Between Peritoneal Dendritic cells and T cells in Ovarian Cancer Patient Ascites: Implications for Cancer Metastasis (2023-2024)
- earned Best Paper in 4th International Conference on Biological Science (2024 ICBioMed)
- earned Outstanding Achievement for Ability and Creativity in In Vitro Bio, MA Science &Engineering Fair (2024 MSEF)
Abstract:
Ovarian Cancer (OC) is a formidable challenge as a gynecological malignancy with ascites, the abnormal accumulation of fluid in the peritoneal cavity, serving as a clinical hallmark of advancement and metastasis. While OC immune analyses focused on solid tumors, little is known about malignant ascites inhabitants during peritoneal metastasis. Here, we focused on a single-cell landscape of the OC ecosystem in malignant ascites with comparison to tumor sites. Our data analysis revealed that comparing to the immunosuppressed tumor, ascites contained less exhausted, more memory-like T cells, which correlated with prolonged survival in stages III/IV OC. Furthermore, we characterized the substantial interactions between dendritic cells and T cells. Lastly, an in vitro dendritic cell culture system from Peripheral Blood Mononuclear Cells (PBMCs) for potential novel cancer vaccine design was explored. Taken together, this study revealed T cell memory and effector potential amidst immunosuppressive pressures in ascites and provided valuable insight into the cross-talk between dendritic cells and T cells that potentially contributes to the unique T cell profile in the ascites ecosystem.
Keywords: Ovarian Cancer (OC), metastasis, malignant ascites, dendritic cells, T cells, cancer vaccine
As the leader of the team, Bolin led 20 people to design and perform experiment to create a novel breast cancer early detection kit using CRISPR-Cas12a cell-free system and circRNA biomarkers. The final result is a 10-minute, non-invasive, hand-sized, and more stable solution for breast cancer early screening. Reaching out and building partnership with other teams in Switzerland, Greece, the U.S., and China, the team organized a global meetup in August, 2022 that invited over 30 teams around the globe to share their projects. The project earned Bronze Medal in International Genetically Engineered Machine competition (iGEM).